PROTOCOL FOR THE ELECTROENCEPHALOGRAPHY GUIDANCE OF ANESTHESIA TO ALLEVIATE GERIATRIC SYNDROMES (ENGAGES-CANADA) STUDY: A PRAGMATIC, RANDOMIZED CLINICAL TRIAL [VERSION 2; PEER REVIEW: 2 APPROVED]

Protocol for the electroencephalography guidance of anesthesia to alleviate geriatric syndromes (ENGAGES-Canada) study: A pragmatic, randomized clinical trial [version 2; peer review: 2 approved]

Background: There is some evidence that electroencephalography guidance of general anesthesia can decrease postoperative delirium after non-cardiac surgery.There is limited evidence in this regard for cardiac surgery.A suppressed electroencephalogram pattern, occurring with deep anesthesia, is associated with increased incidence of postoperative de

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Draft genome sequence of the extremely halophilic Halorubrum sp. SAH-A6 isolated from rock salts of the Danakil depression, Ethiopia

The draft genome sequence of Halorubrum sp.SAH-A6, isolated from commercial rock salts of the Danakil depression, Ethiopia.The genome comprised 3,325,770 bp, HF gear trays with the G + C content of 68.0%.The strain has many genes which are responsible for secondary metabolites biosynthesis, transport and catabolism as compared to other Halorubrum a

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Global protein conjugation by ubiquitin-like-modifiers during ischemic stress is regulated by microRNAs and confers robust tolerance to ischemia.

Hibernation torpor provides an excellent model of natural tolerance to ischemia.We have previously shown that massive global SUMOylation occurs during hibernation torpor in ground squirrels.We have also shown that overexpression of Ubc9, SUMO-1, or SUMO-2/3 provides protection against ischemic damage in cell lines and cortical neurons exposed to ox

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